Autoimmune diseases and seasonal variations

Autoimmune diseases and peptide variations.

The immune system plays an essential role in the defense of the host against invaders. Enormous numbers of lymphocytes are recruited and immense numbers of antibodies or cytokines are secreted in various kinds of immune response. But the system also has the possibility of being the cause of tissue injury or some kind of diseases. For example, when their functions target their host, an autoimmun...

Air Pollution and its Effects on Autoimmune Diseases

Role of Interleukin-37 in Inflammatory and Autoimmune Diseases

Interleukin-1 family 7 (IL-1F7) is a novel member of IL-1F cytokines. IL-1F7 is more commonly known as IL-37. IL-37 join the α-subunit of the IL-18 receptor, or IL-18 binding protein (IL-18BP), and binding of these proteins can enhance the IL-18 suppression. IL-37 also translocates to the cell nucleus and affects gene transcription. IL-37 inhibits the phosphorylation of p38 mitogen-activated pr...

Seasonal variations in cryptorchidism.

The month of birth of boys undergoing orchidopexy in the Oxfordshire Health District during the years 1974-83 was analysed. A significant seasonal variation with a peak in April was found for those boys operated upon by paediatric surgeons at a young age (0-4). Possible causes of this variation and its relationship to the aetiology of cryptorchidism are discussed.

Leptin and Autoimmune Diseases

Introduction: Leptin, an anti-obesity hormone, is also a regulator of the immune response whichsends important signals regarding the metabolic status and immune system function. Thishormone/cytokine can affect the secretion of acute phase proteins such as Interleukin-1 and TNF-αand facilitate communication between nutrition and Th1 immune response so that when the foodintake...